Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-?
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چکیده
منابع مشابه
Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta.
OBJECTIVE The pathological accumulation of extracellular matrix is a characteristic feature of diabetic cardiomyopathy that is directly related to a loss of function. Tranilast (n-[3,4-anthranilic acid), used for the treatment of fibrotic skin diseases, has also been shown to inhibit transforming growth factor-beta (TGF-beta)-induced matrix production in kidney epithelial cells. METHODS To in...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2005
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2004.10.041